Maleyka Karimova 
Azerbaijan Medical University
Baku, Azerbaijan
Doctor of Philosophy in Medicine
dr.karimova@mail.ru
Umida Omonova
Tashkent State Medical University
Tashkent, Uzbekistan
Doctor of Medical Sciences
umidahon1980@mail.ru
Akmaljon Gaybiev
Samarkand State Medical University
Samarkand, Uzbekistan
Doctor of Medical Sciences
akmal_gaybiev@mail.ru
Dilnoza Mirzaeva
Center for the Development of Professional
Qualifications of Medical Workers
Tashkent, Uzbekistan
Doctor of Medical Sciences
dilnozakam80@gmail.com
Jamilya Shagiyasova
Republic Specialized Scientific-Practical
Medical Center of Pediatrics
Tashkent, Uzbekistan
PhD in Medicine
doctor.djamila@mail.ru
Neuroimmune Mechanisms of Respiratory Diseases in Children
With Recurrent Respiratory Infections
Abstract
We aimed to study both the relationship of neuropeptide-P substance with the immune system and its importance in the inflammatory process in children with recurrent respiratory infections (RRI). For this purpose, we examined 340 children with RRI. As a comparison group, 125 children with rare diseases and 120 practically healthy children of similar age were included in the examination. The levels of CD3, CD4, CD8, CD19 cells was determined by the flow cytometry method, the concentration of serum immunoglobulins A, G, M - by G. Mancini's radial immunodiffusion method, the level of IgE was determined by the enzyme immunoassay (IFA) method. The level of IL-1β, IL-2, IL-6, IL-8 and SNF-α cytokines was checked using the "IMMULITE" automatic analyzer using the immunochemiluminescent method (USA), and the level of IFN-γ was checked using the enzyme immunoassay method.
As a result of the conducted research, it was found that neuropeptide substance P, along with the immune system, plays an important role in the pathogenesis of respiratory diseases in children with RRI. As a result of the research, it was found that there is a close correlation between these systems. The non-normalization of the immune system, including cytokine status, substance P indicators during the clinical remission of respiratory diseases in the RRI group indicates the persistence of the infectious agent in these children, and the continuation of the inflammatory process during the clinical remission of the disease.
Keywords: recurrent respiratory infections, children, neuropeptide-P substance, immune system, cytokine, inflammation