Metabolism of the Bilirubin and its Biochemistry Role
Nurgun Mehbaliyeva1 
, Narmina Abdullayeva2* , Nigar Huseynova2
Abstract. Bilirubin is a tetrapyrrolic bile pigment that plays a crucial role in several vital metabolic pathways of the human body. It is a yellow-colored compound that circulates in the bloodstream and participates in various physiological processes. Bilirubin is predominantly generated through the catabolism of hemoglobin following the breakdown of erythrocytes, and its biosynthesis is primarily mediated by the liver. The homeostasis of bilirubin is intricately linked to multiple physiological and biochemical functions, and its precise regulation is essential for maintaining systemic health. Elevated serum bilirubin levels may serve as a clinical biomarker for a range of pathological conditions, including hepatic dysfunctions, hematological disorders, and cholestatic syndromes.
Keywords: bilirubin, free radicals, liver, Kupffer cells, cholesterol